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Cellosaurus A375M2 (CVCL_C0RP)

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Cell line name A375M2
Accession CVCL_C0RP
Resource Identification Initiative To cite this cell line use: A375M2 (RRID:CVCL_C0RP)
Comments Population: Caucasian.
Characteristics: Metastatic. Established from pulmonary metastases obtained afer intravenous injection of the parent cell line into the tail veins of nude mice.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0RN (A375M1)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=10952316; DOI=10.1038/35020106
Edwin A. Clark, Todd Robert Golub, Eric Steven Lander, Richard Olding Hynes;
Genomic analysis of metastasis reveals an essential role for RhoC.
Nature 406:532-535(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0RP
Encyclopedic resources Wikidata; Q112927061
Proteomic databases PRIDE; PXD005277
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7