| Cell line name |
CAL-27 2B1 |
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| Synonyms |
Cal27 2B1; 2B1 |
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| Accession |
CVCL_C0RK |
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| Resource Identification Initiative |
To cite this cell line use: CAL-27 2B1 (RRID:CVCL_C0RK) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6156; ITGB3.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723. |
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| Sequence variations |
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.His193Leu (c.578A>T); ClinVar=VCV000185822; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Tongue adenosquamous carcinoma (NCIt: C173807) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1107 (CAL-27) |
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| Sex of cell |
Male |
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| Age at sampling |
56Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=27108184; DOI=10.1016/j.bbamcr.2016.04.019
Nikolina Stojanovic, Anamaria Brozovic, Dragomira Majhen, Maja Herak Bosnar, Gerhard Fritz, Maja Osmak, Andreja Ambriovic-Ristov;
Integrin alphavbeta3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418).
Biochim. Biophys. Acta 1863:1969-1978(2016) PubMed=34977030; DOI=10.3389/fcell.2021.786758; PMCID=PMC8716755
Ana Tadijan, Jonathan D. Humphries, Ivana Samarzija, Nikolina Stojanovic, Jun-Zhe Zha, Kristina Culjak, Marija Tomic, Mladen Paradzik, Davor Nestic, Heemin Kang, Martin J. Humphries, Andreja Ambriovic-Ristov;
The tongue squamous carcinoma cell line Cal27 primarily employs integrin alpha6beta4-containing type II hemidesmosomes for adhesion which contribute to anticancer drug sensitivity.
Front. Cell Dev. Biol. 9:786758.1-786758.17(2021) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q112929360
|
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| Proteomic databases |
PRIDE; PXD028810
|
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| Entry history |
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| Entry creation | 23-Jun-2022 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 7 |
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