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Cellosaurus U2OS ST-PEAK3 (CVCL_C0QU)

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Cell line name U2OS ST-PEAK3
Accession CVCL_C0QU
Resource Identification Initiative To cite this cell line use: U2OS ST-PEAK3 (RRID:CVCL_C0QU)
Comments Population: Caucasian.
Characteristics: Transfected with a pSBbi-PuroR-ST-PEAK3 that contains a N-terminally Strep-tagged PEAK3.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:24793; PEAK3 (Note=With a N-terminal Strep tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=34944965; DOI=10.3390/cancers13246344; PMCID=PMC8699254
Youcef Ounoughene, Elise Fourgous, Yvan Boublik, Estelle Saland, Nathan Guiraud, Christian Recher, Serge Urbach, Philippe Fort, Jean-Emmanuel Sarry, Didier Fesquet, Serge Roche;
SHED-dependent oncogenic signaling of the PEAK3 pseudo-kinase.
Cancers (Basel) 13:6344.1-6344.18(2021)

Cross-references
Encyclopedic resources Wikidata; Q112930495
Proteomic databases PRIDE; PXD029417
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number8