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Cellosaurus U2OS-PER2-BioID2 (CVCL_C0QF)

[Text version]
Cell line name U2OS-PER2-BioID2
Synonyms U2OS-PER2-13xLinker-BioID2-HA; U2OS-PER2-BioID
Accession CVCL_C0QF
Resource Identification Initiative To cite this cell line use: U2OS-PER2-BioID2 (RRID:CVCL_C0QF)
Comments Population: Caucasian.
Characteristics: Transfected with a MCS-hPER2-13XLinker-BioID2-HA construct which express PER2 fused with the BioID2 protein so as to use proximity-dependent biotin labeling (PubMed=35122331).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:8846; PER2.
Genetic integration: Method=Transfection; Gene=UniProtKB; O66837; Aquifex aeolicus biRA (Note=With p.Arg40Gly = BioID2).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=35122331; DOI=10.1002/prot.26314
Huseyin Gul, Saba Selvi, Fatma Yilmaz, Gozde Ozcelik, Senanur Olfaz-Aslan, Seyma Yazan, Busra Tiryaki, Seref Gul, Ali Yurtseven, Ibrahim Halil Kavakli, Nurhan Ozlu, Nuri Ozturk;
Proteome analysis of the circadian clock protein PERIOD2.
Proteins 90:1315-1330(2022)

Cross-references
Encyclopedic resources Wikidata; Q112930499
Proteomic databases PRIDE; PXD025179
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number8