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Cellosaurus SK-N-AS RET overexpressing clone C1 (CVCL_C0Q9)

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Cell line name SK-N-AS RET overexpressing clone C1
Synonyms SK-N-AS C1
Accession CVCL_C0Q9
Resource Identification Initiative To cite this cell line use: SK-N-AS RET overexpressing clone C1 (RRID:CVCL_C0Q9)
Comments Population: Caucasian.
Characteristics: Was engineered using CRISPR/Cas9 to be a RET KO cell line, but unexpectedly expresses a high level of RET due to a mutation in intron 1 of the RET gene (PubMed=33921066).
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1700 (SK-N-AS)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
Publications

PubMed=33921066; DOI=10.3390/cancers13081909; PMCID=PMC8071449
Joachim T. Siaw, Jonatan L. Gabre, Ezgi Uckun, Marc Vigny, Wan-Cun Zhang, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer, Ji-Kui Guan;
Loss of RET promotes mesenchymal identity in neuroblastoma cells.
Cancers (Basel) 13:1909.1-1909.25(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0Q9
Encyclopedic resources Wikidata; Q112930405
Gene expression databases ArrayExpress; E-MTAB-10032
Proteomic databases PRIDE; PXD024551
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7