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Cellosaurus U2OS-GFP-HK2 (CVCL_C0Q8)

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Cell line name U2OS-GFP-HK2
Accession CVCL_C0Q8
Resource Identification Initiative To cite this cell line use: U2OS-GFP-HK2 (RRID:CVCL_C0Q8)
Comments Population: Caucasian.
Characteristics: Transfected with a pCMV6-AC-HK2-GFP construct that contains HK2 c-terminally tagged with turbo-GFP.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; A315M; TurboGFP (Note=Green fluorescent protein from P.plumata).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4923; HK2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Proteomics; Quantitative.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=35609998; DOI=10.1093/nar/gkac360; PMCID=PMC9178003
Manon Watzky, Solene Huard, Ludmila Juricek, Julien Dairou, Caroline Chauvet, Xavier Coumoul, Anne Letessier, Benoit Miotto;
Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling.
Nucleic Acids Res. 50:5545-5564(2022)

Cross-references
Encyclopedic resources Wikidata; Q112930498
Proteomic databases PRIDE; PXD028992
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number9