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Cellosaurus A549-ACE2 (CVCL_C0Q5)

[Text version]
Cell line name A549-ACE2
Synonyms A549-Ace2
Accession CVCL_C0Q5
Resource Identification Initiative To cite this cell line use: A549-ACE2 (RRID:CVCL_C0Q5)
Comments Group: SARS-CoV-2 research cell line.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=33208793; DOI=10.1038/s41467-020-19619-7; PMCID=PMC7676268
Steffen Klein, Mirko Cortese, Sophie L. Winter, Moritz Wachsmuth-Melm, Christopher J. Neufeldt, Berati Cerikan, Megan L. Stanifer, Steeve Boulant, Ralf Friedrich Wilhelm Bartenschlager, Petr Chlanda;
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography.
Nat. Commun. 11:5885.1-5885.10(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0Q5
Encyclopedic resources Wikidata; Q112927063
Gene expression databases GEO; GSM5224710
GEO; GSM5224711
GEO; GSM5224712
Proteomic databases PRIDE; PXD019645
PRIDE; PXD023418
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number8