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Cellosaurus XL58-TRE-Luc (CVCL_C0ND)

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Cell line name XL58-TRE-Luc
Accession CVCL_C0ND
Resource Identification Initiative To cite this cell line use: XL58-TRE-Luc (RRID:CVCL_C0ND)
Comments Group: Amphibian cell line.
Biotechnology: Used in a thyroid hormone (TH) inducible primary screening assay for the identification and assessment of chemicals that interfere with the TH-signalling pathway within target cells (PubMed=16179385).
Characteristics: Expression of luciferase is under the control of Xenopus T3-response elements (TREs). Expression of EGFP is under the control of the CMV promoter.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Species of origin Xenopus laevis (African clawed frog) (NCBI Taxonomy: 8355)
Hierarchy Parent: CVCL_C0NC (XL58)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Spontaneously immortalized cell line
Publications

PubMed=16102758; DOI=10.1016/j.ygcen.2005.06.003
Shin-ichiro Sugiyama, Hiroyuki Miyoshi, Kiyoshi Yamauchi;
Characteristics of a thyroid hormone responsive reporter gene transduced into a Xenopus laevis cell line using lentivirus vector.
Gen. Comp. Endocrinol. 144:270-279(2005)

PubMed=16179385; DOI=10.1093/toxsci/kfi330
Shin-ichiro Sugiyama, Naoki Shimada, Hiroyuki Miyoshi, Kiyoshi Yamauchi;
Detection of thyroid system-disrupting chemicals using in vitro and in vivo screening assays in Xenopus laevis.
Toxicol. Sci. 88:367-374(2005)

Cross-references
Encyclopedic resources Wikidata; Q112930580
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number6