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Cellosaurus HEK293::TMEM192-3xHA APP-/- (CVCL_C0I6)

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Cell line name HEK293::TMEM192-3xHA APP-/-
Synonyms 293L-APP-/-
Accession CVCL_C0I6
Resource Identification Initiative To cite this cell line use: HEK293::TMEM192-3xHA APP-/- (RRID:CVCL_C0I6)
Comments Characteristics: Using CRISPR/Cas9 TMEM192 was C-terminally tagged on both alleles with a 3xHA epitope (from parent cell line).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0I5 (HEK293::TMEM192-3xHA)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=36245040; DOI=10.1038/s41467-022-33881-x; PMCID=PMC9573879
Hankum Park, Frances V. Hundley, Qing Yu, Katherine A. Overmyer, Dain R. Brademan, Lia Serrano, Joao A. Paulo, Julia C. Paoli, Sharan Swarup, Joshua J. Coon, Steven P. Gygi, Jeffrey Wade Harper;
Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics.
Nat. Commun. 13:6112.1-6112.21(2022)

Cross-references
Encyclopedic resources Wikidata; Q112926930
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number9