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Cellosaurus K562/G (CVCL_C0HT)

[Text version]
Cell line name K562/G
Accession CVCL_C0HT
Resource Identification Initiative To cite this cell line use: K562/G (RRID:CVCL_C0HT)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=21122350; DOI=10.3760/cma.j.issn.0253-2727.2010.06.003
Hong-Yun Jia, Xiao-Man Wu, Zhong-Ying Wang, Xiao-Yan Deng, Zhen Lin, Gui-Ling Feng, Wen-Lin Huang;
Effect of ZD6474 on the proliferation of imatinib-resistant K562 cells.
Zhonghua Xue Ye Xue Za Zhi 31:371-375(2010)

Cross-references
Encyclopedic resources Wikidata; Q112929938
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6