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Cellosaurus HTR.B7-1 (CVCL_C0DG)

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Cell line name HTR.B7-1
Synonyms P1.HTR.B7-1
Accession CVCL_C0DG
Resource Identification Initiative To cite this cell line use: HTR.B7-1 (RRID:CVCL_C0DG)
Comments Selected for resistance to: ChEBI; CHEBI_472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:101775; Cd80.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Sequence variations
  • Mutation; MGI; MGI:96677; Kit; Simple; p.Asp818Tyr (c.2452G>T) (D814Y); Zygosity=Unspecified (from parent cell line).
Disease Mouse mast cell neoplasm (NCIt: C21632)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Parent: CVCL_4265 (P1.HTR)
Children:
CVCL_C0DH (HTR.B7-1/C)CVCL_C0DI (HTR.B7-1/B7-2)CVCL_C0DJ (HTR.B7-1/IL-12)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=8609411; DOI=10.4049/jimmunol.156.8.2909
Thomas F. Gajewski, Francesca Fallarino, Catherine Uyttenhove, Thierry Boon;
Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
J. Immunol. 156:2909-2917(1996)

PubMed=9310829; DOI=10.1093/intimm/9.9.1259
Francesca Fallarino, Andrew Ashikari, Thierry Boon, Thomas F. Gajewski;
Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells.
Int. Immunol. 9:1259-1269(1997)

Cross-references
Encyclopedic resources Wikidata; Q112929780
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number6