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Cellosaurus RMA.Trh4 (CVCL_C0DC)

[Text version]
Cell line name RMA.Trh4
Accession CVCL_C0DC
Resource Identification Initiative To cite this cell line use: RMA.Trh4 (RRID:CVCL_C0DC)
Comments Characteristics: This cell line provides a model to help to understand T-cell recognition through Cers5/Trh4 expression (Ximbio=157676).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:1919199; Cers5.
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Transformant: NCBI_TaxID; 11938; Rauscher murine leukemia virus (R-MuLV).
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: T-cell; CL=CL_0000084.
Disease Mouse leukemia (NCIt: C21604)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_J385 (RMA)
Children:
CVCL_C0DE (RMA.Trh4 Db KO)CVCL_C0DQ (RMA.Trh4 Kb KO)
Category Cancer cell line
Publications

PubMed=21898382; DOI=10.1002/eji.201141836
Oliveira C.C., Querido B.J., Sluijter M., Derbinski J., van der Burg S.H., van Hall T.
Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires.
Eur. J. Immunol. 41:3114-3124(2011)

PubMed=29399388; DOI=10.1080/2162402X.2017.1382793; PMCID=PMC5790395
Doorduijn E.M., Sluijter M., Marijt K.A., Querido B.J., van der Burg S.H., van Hall T.
T cells specific for a TAP-independent self-peptide remain naive in tumor-bearing mice and are fully exploitable for therapy.
OncoImmunology 7:e1382793.1-e1382793.10(2018)

Cross-references
Cell line collections (Providers) CancerTools; 157676
Ximbio; 157676
Encyclopedic resources Wikidata; Q114312802
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number8