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Cellosaurus HEL 92.1.7 SOD2 KO clone 13 (CVCL_C0D1)

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Cell line name HEL 92.1.7 SOD2 KO clone 13
Synonyms HEL SOD2-/- clone 13; SOD2-/- HEL clone 13; SOD2-/- cl.13
Accession CVCL_C0D1
Resource Identification Initiative To cite this cell line use: HEL 92.1.7 SOD2 KO clone 13 (RRID:CVCL_C0D1)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11180; SOD2.
Donor information: Originally the patient was suffering from Hodgkin lymphoma.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Lys (c.398T>A); ClinVar=VCV002430159; Zygosity=Homozygous (from parent cell line).
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2481 (HEL 92.1.7)
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=33585836; DOI=10.33696/pathology.1.009; PMCID=PMC7876477
Kimberly L. Cramer-Morales, Collin D. Heer, Kranti A. Mapuskar, Frederick E. Domann;
Succinate accumulation links mitochondrial MnSOD depletion to aberrant nuclear DNA methylation and altered cell fate.
J. Exp. Pathol. (Wilmington) 1:60-70(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0D1
Encyclopedic resources Wikidata; Q112929700
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7