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Cellosaurus UPPL1541 (CVCL_C0CT)

[Text version]
Cell line name UPPL1541
Accession CVCL_C0CT
Resource Identification Initiative To cite this cell line use: UPPL1541 (RRID:CVCL_C0CT)
Comments Characteristics: Displays a similar expression profiles to luminal-like molecular subtype bladder cancers in humans (ABM=T8245).
Doubling time: 24-36 hours (ABM=T8245).
Knockout cell: Method=KO mouse; MGI; MGI:109583; Pten.
Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:1352467; Esr1 (Note=Ligand binding domain; with p.Gly525Arg. Fused to Cre = CreERT2).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P06956; Escherichia phage P1 cre (Note=Fused to ligand domain of mouse Esr1 = CreERT2).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Cell type: Urothelial cell; CL=CL_0000731.
Disease Mouse bladder transitional cell carcinoma (NCIt: C25823)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 Upk3a-CreERT2, Trp53L/L, PtenL/L, Rosa26LSL-Luc transgenic.
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=29784854; DOI=10.1158/0008-5472.CAN-18-0173; PMCID=PMC6157276
Saito R., Smith C.C., Utsumi T., Bixby L.M., Kardos J., Wobker S.E., Stewart K.G., Chai S.-J., Manocha U., Byrd K.M., Damrauer J.S., Williams S.E., Vincent B.G., Kim W.Y.
Molecular subtype-specific immunocompetent models of high-grade urothelial carcinoma reveal differential neoantigen expression and response to immunotherapy.
Cancer Res. 78:3954-3968(2018)

Cross-references
Cell line collections (Providers) ABM; T8245
Encyclopedic resources Wikidata; Q112930527
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7