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Cellosaurus PC-6 (CVCL_C002)

[Text version]
Cell line name PC-6
Synonyms PC 6; PC6
Accession CVCL_C002
Resource Identification Initiative To cite this cell line use: PC-6 (RRID:CVCL_C002)
Comments From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
Population: Japanese.
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_ZZ74 (PC-6/ADM2-1)CVCL_ZZ79 (PC-6/AMR-OH)CVCL_ZZ75 (PC-6/CDDP2-7)
CVCL_ZZ76 (PC-6/CPT2-2)CVCL_ZZ73 (PC-6/FU23-26)CVCL_S850 (PC-6/SN2-5)
CVCL_S849 (PC-6/TAX1-1)CVCL_ZZ77 (PC-6/VCR29-9)CVCL_ZZ78 (PC-6/VP1-1)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2982333
Masanori Terashima, Katsuhiro Inoue, Taketo Mukaiyama, Ikuo Mitsui, Makoto Ogawa;
Enhanced cytotoxic effect of adriamycin and vincristine against PC-6 (human lung cancer cell line) and Hattori (human breast cancer cell line).
Gan To Kagaku Ryoho 12:343-347(1985)

PubMed=3731100
Nobuo Hanai, Kenya Shitara, Hajime Yoshida;
Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung.
Cancer Res. 46:4438-4443(1986)

PubMed=9259410; DOI=10.1002/(SICI)1097-0215(19970807)72:4<680::AID-IJC21>3.0.CO;2-E
Noriko Joto, Mineko Ishii, Megumi Minami, Hiroshi Kuga, Ikuo Mitsui, Akiko Tohgo;
DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant.
Int. J. Cancer 72:680-686(1997)

PubMed=10912951; DOI=10.1097/00001813-200006000-00005
Mineko Ishii, Michio Iwahana, Ikuo Mitsui, Megumi Minami, Setsuko Imagawa, Akiko Tohgo, Akio Ejima;
Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6.
Anticancer Drugs 11:353-362(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681
Sana Yokoi, Kohichiroh Yasui, Fumiko Saito-Ohara, Katsumi Koshikawa, Toshihiko Iizasa, Takehiko Fujisawa, Takeo Terasaki, Akira Horii, Takashi Takahashi, Setsuo Hirohashi, Johji Inazawa;
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254
Haruko Yamaji, Toshihiko Iizasa, Eitetsu Koh, Makoto Suzuki, Mizuto Otsuji, Hao Chang, Shinichiro Motohashi, Sana Yokoi, Kenzo Hiroshima, Masatoshi Tagawa, Toshinori Nakayama, Takehiko Fujisawa;
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529
Tetsuya Oguri, Yuji Bessho, Hiroyuki Achiwa, Hiroaki Ozasa, Ken Maeno, Hiroyoshi Maeda, Shigeki Sato, Ryuzo Ueda;
MRP8/ABCC11 directly confers resistance to 5-fluorouracil.
Mol. Cancer Ther. 6:122-127(2007)

PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702
Takashi Fukuyama, Yoshinobu Ichiki, Sousuke Yamada, Yoshiki Shigematsu, Tetsuro Baba, Yoshika Nagata, Makiko Mizukami, Masakazu Sugaya, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto;
Cytokine production of lung cancer cell lines: correlation between their production and the inflammatory/immunological responses both in vivo and in vitro.
Cancer Sci. 98:1048-1054(2007)

PubMed=18445659; DOI=10.1158/1535-7163.MCT-07-2088
Tetsuya Oguri, Hiroaki Ozasa, Takehiro Uemura, Yuji Bessho, Mikinori Miyazaki, Ken Maeno, Hiroyoshi Maeda, Shigeki Sato, Ryuzo Ueda;
MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
Mol. Cancer Ther. 7:1150-1155(2008)

PubMed=21128075; DOI=10.1007/s00280-010-1533-4
Osamu Takakuwa, Tetsuya Oguri, Hiroaki Ozasa, Takehiro Uemura, Daishi Kasai, Mikinori Miyazaki, Ken Maeno, Shigeki Sato;
Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.
Cancer Chemother. Pharmacol. 68:669-676(2011)

Cross-references
Cell line databases/resources CGH-DB; 105-1
CGH-DB; 9051-4
Chemistry resources ChEMBL-Cells; CHEMBL3307571
ChEMBL-Targets; CHEMBL614235
PubChem_Cell_line; CVCL_C002
Encyclopedic resources Wikidata; Q54938461
Experimental variables resources EFO; EFO_0002845
Polymorphism and mutation databases Cosmic; 1212199
Cosmic; 1571745
Entry history
Entry creation06-Jun-2012
Last entry update21-Mar-2023
Version number15