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Cellosaurus MasterShef10 (CVCL_BW82)

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Cell line name MasterShef10
Synonyms MasterShef 10; MstrShef10; MShef10; UOSe014-A
Accession CVCL_BW82
Resource Identification Initiative To cite this cell line use: MasterShef10 (RRID:CVCL_BW82)
Comments Group: Clinical grade pluripotent cell line.
From: University of Sheffield; Sheffield; United Kingdom.
Registration: UK Stem Cell Bank (UKSCB); C-16-020, Steering comm. appl. SCSC13-05.
Omics: Genomics; Whole exome sequencing.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
Web pages Provider; NIBSC; -; https://nibsc.org/science_and_research/advanced_therapies/uk_stem_cell_bank/cell_line_catalogue/eutcd_grade_.aspx
Publications

PubMed=26607962; DOI=10.1038/srep17258; PMCID=PMC4660465
Maurice A. Canham, Amy Lynnette Van Deusen, Daniel Roy Brison, Paul Alexandre De Sousa, Janet M. Downie, Liani Gasparini Devito, Zoe A. Hewitt, Dusko Ilic, Susan J. Kimber, Harry D. Moore, Helen Murray, Tilo Kunath;
The molecular karyotype of 25 clinical-grade human embryonic stem cell lines.
Sci. Rep. 5:17258.1-17258.13(2015)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources hPSCreg; UOSe014-A
Biological sample resources BioSamples; SAMEA104627967
Encyclopedic resources Wikidata; Q54904041
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number16