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Cellosaurus McWT2 (CVCL_B9UY)

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Cell line name McWT2
Synonyms 14d; L14
Accession CVCL_B9UY
Resource Identification Initiative To cite this cell line use: McWT2 (RRID:CVCL_B9UY)
Comments Omics: Transcriptomics; Microarray.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6J.
Sex of cell Female
Age at sampling 1D
Category Spontaneously immortalized cell line
Publications

PubMed=18006687; DOI=10.1101/gad.450107; PMCID=PMC2049194
Veronique Delmas, Friedrich Beermann, Silvia Martinozzi, Suzanne Carreira, Julien Ackermann, Mayuko Kumasaka, Laurence Denat, Jane Goodall, Flavie Luciani, Amaya Viros, Nese Demirkan ...Show all 14 authors... , Boris C. Bastian, Colin Ronald Goding, Lionel Larue; Show fewer authors
Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development.
Genes Dev. 21:2923-2935(2007)

PubMed=31251472; DOI=10.1111/pcmr.12807
Valerie Petit, Jeremy Raymond, Christophe Alberti, Marie Pouteaux, Stuart J. Gallagher, Mai Q. Nguyen, Andrew E. Aplin, Veronique Delmas, Lionel Larue;
C57BL/6 congenic mouse NRAS(Q61K) melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo.
Pigment Cell Melanoma Res. 32:829-841(2019)

Cross-references
Encyclopedic resources Wikidata; Q112930098
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number5