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Cellosaurus McNRAS2 (CVCL_B9UW)

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Cell line name McNRAS2
Synonyms 91a; 91A; R91a; RAS91
Accession CVCL_B9UW
Resource Identification Initiative To cite this cell line use: McNRAS2 (RRID:CVCL_B9UW)
Comments Genetic integration: Method=Transgenic mouse; Gene=HGNC; HGNC:7989; NRAS (Note=With p.Gln61Lys).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: ((C57BL/6J x DBA/2) Tg(Tyr-NRAS*Q61K)1Bee transgenic x C57BL/6J) F2.
Sex of cell Male
Age at sampling 1D
Category Spontaneously immortalized cell line
Publications

PubMed=31251472; DOI=10.1111/pcmr.12807
Valerie Petit, Jeremy Raymond, Christophe Alberti, Marie Pouteaux, Stuart J. Gallagher, Mai Q. Nguyen, Andrew E. Aplin, Veronique Delmas, Lionel Larue;
C57BL/6 congenic mouse NRAS(Q61K) melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo.
Pigment Cell Melanoma Res. 32:829-841(2019)

Cross-references
Encyclopedic resources Wikidata; Q112930096
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7