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Cellosaurus ESI-035 (CVCL_B856)

[Text version]
Cell line name ESI-035
Synonyms ESI035; SSCCe007-A
Accession CVCL_B856
Resource Identification Initiative To cite this cell line use: ESI-035 (RRID:CVCL_B856)
Comments Group: Clinical grade pluripotent cell line.
From: ESI BIO - BioTime, Inc. (ES Cell International); Alameda; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-11-0129.
Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC14-01.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Gly (c.817C>G); ClinVar=VCV000634682; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
STR profile Source(s): ESI BIO

Penta D9,12
Penta E11,14

Run an STR similarity search on this cell line
Web pages http://www.esibio.com/products/product-category/cell-lines/esi-035-human-embryonic-stem-cell-line-46-xx/

PubMed=18371388; DOI=10.1016/j.stem.2007.10.004
Crook J.M., Peura T.T., Kravets L., Bosman A.G., Buzzard J.J., Horne R., Hentze H., Dunn N.R., Zweigerdt R., Chua F., Upshall A., Colman A.
The generation of six clinical-grade human embryonic stem cell lines.
Cell Stem Cell 1:490-494(2007)

PubMed=20177998; DOI=10.1007/s11626-010-9287-1
Sivarajah S., Raj G.S., Mathews A.J.V., Sahib N.B.E., Hwang W.-S., Crook J.M.
The generation of GLP-grade human embryonic stem cell banks from four clinical-grade cell lines for preclinical research.
In Vitro Cell. Dev. Biol. Anim. 46:210-216(2010)

PubMed=22265736; DOI=10.1016/j.scr.2011.10.001
Funk W.D., Labat I., Sampathkumar J., Gourraud P.-A., Oksenberg J.R., Rosler E.S., Steiger D., Sheibani N., Caillier S., Stache-Crain B., Johnson J.A., Meisner L.F., Lacher M.D., Chapman K.B., Park M.J., Shin K.-J., Drmanac R., West M.D.
Evaluating the genomic and sequence integrity of human ES cell lines comparison to normal genomes.
Stem Cell Res. 8:154-164(2012)

PubMed=28445466; DOI=10.1038/nature22312
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Nature 545:229-233(2017)

Cell line databases/resources hPSCreg; SSCCe007-A
ISCR; 81
NIHhESC; NIHhESC-11-0129
SKIP; SKIP002091
Encyclopedic resources Wikidata; Q54832758
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number19