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Cellosaurus CyT49 (CVCL_B850)

[Text version]
Cell line name CyT49
Synonyms VCYTe001-A
Accession CVCL_B850
Resource Identification Initiative To cite this cell line use: CyT49 (RRID:CVCL_B850)
Comments From: ViaCyte, Inc. (originally from CyThera, Novocell); San Diego; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0041.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
STR profile Source(s): Novocell

Markers:
CSF1PO11,12
D3S135816,17
D5S81810,11
D7S82010,12
D8S117912,16
D13S31711,12
D16S5399,12
D18S5112,18
D21S1128
FGA21,23
Penta E17,20
TH019.3
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; LifeMap Discovery; -; https://web.archive.org/web/20221104000358/https://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/inner-cell-mass-homo-sapiens-cyt49-viacyte-novocell-san-diego-ca
Publications

PubMed=18288110; DOI=10.1038/nbt1393
Evert J. Kroon, Laura A. Martinson, Kuniko Kadoya, Anne G. Bang, Olivia G. Kelly, Susan Eliazer, Holly Y. Young, Mike Richardson, Nora G. Smart, Justine Cunningham, Alan D. Agulnick ...Show all 14 authors... , Kevin A. D'Amour, Melissa K. Carpenter, Emmanuel Edward Baetge; Show fewer authors
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.
Nat. Biotechnol. 26:443-452(2008)

PubMed=22623968; DOI=10.1371/journal.pone.0037004; PMCID=PMC3356395
Thomas C. Schulz, Holly Y. Young, Alan D. Agulnick, M. Josephine Babin, Emmanuel Edward Baetge, Anne G. Bang, Anindita Bhoumik, Igor Cepa, Rosemary M. Cesario, Carl Haakmeester, Kuniko Kadoya ...Show all 28 authors... , Jonathan R. Kelly, Justin Kerr, Laura A. Martinson, Amanda B. McLean, Mark A. Moorman, Janice K. Payne, Mike Richardson, Kelly G. Ross, Eric S. Sherrer, Xue-Hong Song, Alistair Z. Wilson, Eugene P. Brandon, Chad E. Green, Evert J. Kroon, Olivia G. Kelly, Kevin A. D'Amour, Allan J. Robins; Show fewer authors
A scalable system for production of functional pancreatic progenitors from human embryonic stem cells.
PLoS ONE 7:e37004.1-e37004.17(2012)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources hPSCreg; VCYTe001-A
NIHhESC; NIHhESC-10-0041
SKIP; SKIP002593
Biological sample resources BioSamples; SAMEA17469418
ENCODE; ENCBS882LFH
ENCODE; ENCBS976TXC
Encyclopedic resources Wikidata; Q54817112
Experimental variables resources EFO; EFO_0007073
Gene expression databases GEO; GSM1548607
GEO; GSM1548608
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number23