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Cellosaurus e-hOB-2 (CVCL_B7UA)

[Text version]
Cell line name e-hOB-2
Accession CVCL_B7UA
Resource Identification Initiative To cite this cell line use: e-hOB-2 (RRID:CVCL_B7UA)
Comments Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=29520052).
Karyotypic information: 40-47<2n>add(X)(q27),add(10)(p11),-13,add(14)(q32),+20,+21,+22 (PubMed=29520052).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3527; EZH2.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3796; FOS.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88138; Bcl2.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
Genetic integration: Method=Transduction; Gene=MGI; MGI:99187; Zfp42.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Cell type: Osteoblast; CL=CL_0000062.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B7U9 ! e-hOB-1
CVCL_B7UB ! e-hOB-3
CVCL_B7UC ! e-hOB-4
Sex of cell Female
Category Transformed cell line
Publications

PubMed=29520052; DOI=10.1038/s41467-018-03408-4; PMCID=PMC5843645
Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J., Truschel T., Luckner M., Koster M., MacLeod R.A.F., Pezoldt J., Huhn J., Yuan Q.-G., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O., Pufe T., Beckmann R., Drescher W., Riancho J.A., Sanudo C., Korff T., Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R., Hauser H., Wirth D., May T.
Expansion of functional personalized cells with specific transgene combinations.
Nat. Commun. 9:994.1-994.12(2018)

Cross-references
Encyclopedic resources Wikidata; Q112929493
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7