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Cellosaurus RIL175-R (CVCL_B7TN)

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Cell line name RIL175-R
Accession CVCL_B7TN
Resource Identification Initiative To cite this cell line use: RIL175-R (RRID:CVCL_B7TN)
Comments Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
Selected for resistance to: ChEBI; CHEBI_50924; Sorafenib (Nexavar).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_B7TK (RIL-175)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Cancer cell line
Publications

DOI=10.5282/edoc.26548
Martina Messner;
Sorafenib resistance of hepatocellular carcinoma: antibiotics second- line to sorafenib therapy inhibit mitochondrial biogenesis and prevent tumor growth resumption.
Thesis PhD (2020); Ludwig Maximilians University of Munich; Munich; Germany

PubMed=32652772; DOI=10.1096/fj.202001128R
Martina Messner, Sabine Schmitt, Maximilian Alexander Ardelt, Thomas Frohlich, Martin Muller, Helmut Pein, Petra Huber-Cantonati, Carina Ortler, Lars M. Koenig, Lena Zobel, Andreas Koeberle ...Show all 18 authors... , Georg J. Arnold, Simon Rothenfusser, Alexandra K. Kiemer, Alexander L. Gerbes, Hans Zischka, Angelika M. Vollmar, Johanna Pachmayr; Show fewer authors
Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.
FASEB J. 34:11860-11882(2020)

Cross-references
Encyclopedic resources Wikidata; Q114312789
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number7