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Cellosaurus K562/A*0201 (CVCL_B7RM)

[Text version]
Cell line name K562/A*0201
Accession CVCL_B7RM
Resource Identification Initiative To cite this cell line use: K562/A*0201 (RRID:CVCL_B7RM)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:4931; HLA-A (Note=Allele A*02:01).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=11730845; DOI=10.1016/S0022-1759(01)00499-9
Cedrik M. Britten, Ralf G. Meyer, Tanja Kreer, Ingo Drexler, Thomas Wolfel, Wolfgang Herr;
The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8(+) T lymphocytes in IFN-gamma ELISPOT assays.
J. Immunol. Methods 259:95-110(2002)

Cross-references
Encyclopedic resources Wikidata; Q112929937
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number8