Cellosaurus cell line TH4-7-5 (CVCL

Cellosaurus TH4-7-5 (CVCL_B7RA)

Cross-references
Cell line name	TH4-7-5
Accession	CVCL_B7RA
Resource Identification Initiative	To cite this cell line use: TH4-7-5 (RRID:CVCL_B7RA)
Comments	Group: Patented cell line. Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-861. Virology: In vitro persistently infected by HIV-1. Produces substantial amounts of Nef (PubMed=1373627). Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Disease	Astrocytoma (NCIt: C60781) Astrocytoma (ORDO: Orphanet_94)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_B7R9 (85HG-66)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	Patent=WO1990015150A1 Volker Erfle, Werner Mellert; Process for obtaining a regulation protein (nef) for HIV-1 using the human cell line TH4-7-5. Patent number WO1990015150A1, 13-Dec-1990 PubMed=1373627; DOI=10.1097/00002030-199203000-00004 Ruth Brack-Werner, Andrea Kleinschmidt, Alexandra Ludvigsen, Werner Mellert, Markus Neumann, Reiner Herrmann, Marinee Chuah-Lay Khim, Arsene Burny, Nikolaus Muller-Lantzsch, Dimitrios Stavrou, Volker Erfle; Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. AIDS 6:273-285(1992) Patent=DE3940527C2 Volker Erfle, Werner Mellert; Human cell line TH4-7-5, its use and method for producing a protein product of an HIV regulatory gene. Patent number DE3940527C2, 07-Aug-1997
Encyclopedic resources	Wikidata; Q112930468
Entry history
Entry creation	23-Jun-2022
Last entry update	29-Jun-2023
Version number	5