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Cellosaurus PC3PR (CVCL_B7P9)

[Text version]
Cell line name PC3PR
Synonyms PC3-PR
Accession CVCL_B7P9
Resource Identification Initiative To cite this cell line use: PC3PR (RRID:CVCL_B7P9)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=20687223; DOI=10.1002/pros.21185
Kojima K., Fujita Y., Nozawa Y., Deguchi T., Ito M.
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms.
Prostate 70:1501-1512(2010)

PubMed=23876400; DOI=10.1016/j.cyto.2013.06.313
Kato T., Fujita Y., Nakane K., Mizutani K., Terazawa R., Ehara H., Kanimoto Y., Kojima T., Nozawa Y., Deguchi T., Ito M.
CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling.
Cytokine 64:251-257(2013)

PubMed=27687545; DOI=10.1016/j.bbrc.2016.09.128
Sobue S., Mizutani N., Aoyama Y., Kawamoto Y., Suzuki M., Nozawa Y., Ichihara M., Murate T.
Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel.
Biochem. Biophys. Res. Commun. 479:808-813(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7P9
Encyclopedic resources Wikidata; Q112930288
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5