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Cellosaurus HCC827-HGF2 (CVCL_B7N3)

[Text version]
Cell line name HCC827-HGF2
Accession CVCL_B7N3
Resource Identification Initiative To cite this cell line use: HCC827-HGF2 (RRID:CVCL_B7N3)
Comments Population: Caucasian.
Transfected with: HGNC; 4893; HGF.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=20716641; DOI=10.1158/1535-7163.MCT-10-0481
Okamoto W., Okamoto I., Tanaka K., Hatashita E., Yamada Y., Kuwata K., Yamaguchi H., Arao T., Nishio K., Fukuoka M., Janne P.A., Nakagawa K.
TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation.
Mol. Cancer Ther. 9:2785-2792(2010)

Cell line databases/resources cancercelllines; CVCL_B7N3
Encyclopedic resources Wikidata; Q112929642
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5