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Cellosaurus HCC827-HGF2 (CVCL_B7N3)

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Cell line name HCC827-HGF2
Accession CVCL_B7N3
Resource Identification Initiative To cite this cell line use: HCC827-HGF2 (RRID:CVCL_B7N3)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4893; HGF.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=20716641; DOI=10.1158/1535-7163.MCT-10-0481; PMCID=PMC3208321
Wataru Okamoto, Isamu Okamoto, Kaoru Tanaka, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Haruka Yamaguchi, Tokuzo Arao, Kazuto Nishio, Masahiro Fukuoka, Pasi Antero Janne, Kazuhiko Nakagawa;
TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation.
Mol. Cancer Ther. 9:2785-2792(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7N3
Encyclopedic resources Wikidata; Q112929642
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7