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Cellosaurus FDOVL (CVCL_B7MN)

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Cell line name FDOVL
Accession CVCL_B7MN
Resource Identification Initiative To cite this cell line use: FDOVL (RRID:CVCL_B7MN)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China General Microbiological Culture Collection Center; CGMCC No.15484.
Population: Chinese.
Doubling time: 87 hours (Patent=CN110835623B; PubMed=36982170).
Omics: Genomics; Whole exome sequencing.
Derived from site: Metastatic; Pelvic lymph node; UBERON=UBERON_0015876.
Sequence variations
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Ile1432Thr (c.4295C>T); Zygosity=Homozygous (PubMed=36982170).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Cys702fs (c.2104_2111del); Zygosity=Heterozygous (PubMed=36982170).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu252del (c.754_756delCTC); ClinVar=VCV000998484; Zygosity=Heterozygous (PubMed=36982170).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

Patent=CN110835623B
Wei Jiang, Hui-Juan Yang, Wen-Tao Yang, Li-Bing Xiang, Ying-Ying Zheng, Tian-Cong He, Xuan Pei;
Primary platinum-resistant human ovarian cancer cell line FDOVL, and preparation method and application thereof.
Patent number CN110835623B, 30-Aug-2022

PubMed=36982170; DOI=10.3390/ijms24065091; PMCID=PMC10049685
Wei Jiang, Xue-Yan Ouyang, Chun-Juan Jiang, Li-Na Yin, Qian-Lan Yao, Xuan Pei, Zhao-Dong Ji, Ming Li, Shao-Li Song, Wen-Tao Yang, Sheng-Lin Huang ...Show all 13 authors... , Hui-Juan Yang, Bo-Er Shan; Show fewer authors
A NOTCH1 mutation found in a newly established ovarian cancer cell line (FDOVL) promotes lymph node metastasis in ovarian cancer.
Int. J. Mol. Sci. 24:5091.1-5091.19(2023)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7MN
Encyclopedic resources Wikidata; Q112929560
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number8