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Cellosaurus BC-PAK1 (CVCL_B7IM)

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Cell line name BC-PAK1
Synonyms BC-PAK-1
Accession CVCL_B7IM
Resource Identification Initiative To cite this cell line use: BC-PAK1 (RRID:CVCL_B7IM)
Comments Population: Pakistani.
Characteristics: ER-positive, PR-positive and ERBB2-negative.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:14214; CIC; Simple; p.Ala1591Alafs*28 (c.4773T>TGC); Zygosity=Heterozygous (PubMed=34495459).
  • Mutation; HGNC; HGNC:13726; KMT2C; Simple; p.Tyr987Ter (c.2961C>G); ClinVar=VCV000694634; Zygosity=Heterozygous (PubMed=34495459).
  • Mutation; HGNC; HGNC:8554; PABPC1; Simple; p.Lys333Lysfs*21 (c.999delT); Zygosity=Heterozygous (PubMed=34495459).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
Publications

CLPUB00697
Anum Jabeen Mughal;
Establishment and characterization of human breast cancer cell line of Pakistani origin.
Thesis MSc (2015); University of Karachi; Karachi; Pakistan

PubMed=34495459; DOI=10.1007/s11033-021-06681-7
Muhammad Shakeel, Salman Ahmed Khan, Anum Jabeen Mughal, Muhammad Irfan, Daniel Christian Hoessli, M. Iqbal Choudhary, Muhammad Aurongzeb, Ishtiaq Ahmad Khan;
Distinct genetic landscape and a low response to doxorubicin in a luminal-A breast cancer cell line of Pakistani origin.
Mol. Biol. Rep. 48:6821-6829(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7IM
Encyclopedic resources Wikidata; Q112929280
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number8