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Cellosaurus Mel JuSo ABCB5 KO clone HO2 (CVCL_B7EG)

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Cell line name Mel JuSo ABCB5 KO clone HO2
Accession CVCL_B7EG
Resource Identification Initiative To cite this cell line use: Mel JuSo ABCB5 KO clone HO2 (RRID:CVCL_B7EG)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:46; ABCB5.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012604; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1403 (Mel JuSo)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

CLPUB00695
Emilie Guerit;
Generation of an ABCB5-knockout human melanoma cell line using the CRISPR/Cas9 genome editing-tool: study of ABCB5 subcellular localization by cell fractionation.
Thesis MSc (2019); University of Namur; Namur; Belgium

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7EG
Encyclopedic resources Wikidata; Q112930109
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7