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Cellosaurus CCRF-CEM C7-SC2/HDR (CVCL_B7AL)

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Cell line name CCRF-CEM C7-SC2/HDR
Synonyms CEM-C7-SC2/HDR
Accession CVCL_B7AL
Resource Identification Initiative To cite this cell line use: CCRF-CEM C7-SC2/HDR (RRID:CVCL_B7AL)
Comments Population: Caucasian.
Characteristics: Made glucocorticoid resistant by culturing the parent cell line under hypoxia for 5 weeks after a single dexamethasone (Dex) treatment (PubMed=31221196).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B7AJ (CCRF-CEM C7-SC2)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=31221196; DOI=10.1186/s13046-019-1280-2; PMCID=PMC6585113
Ling Gu, Ge Zhang, Yan-Le Zhang;
A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines.
J. Exp. Clin. Cancer Res. 38:269.1-269.12(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7AL
Encyclopedic resources Wikidata; Q111733085
Entry history
Entry creation17-Mar-2022
Last entry update10-Apr-2025
Version number7