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Cellosaurus alphaTC1-6 ins2:eGFP (CVCL_B6YB)

[Text version]
Cell line name alphaTC1-6 ins2:eGFP
Synonyms ins2:eGFP alphaTC1-6; pcDNA3.1-Puro-ins2-eGFP alphaTC1-6
Accession CVCL_B6YB
Resource Identification Initiative To cite this cell line use: alphaTC1-6 ins2:eGFP (RRID:CVCL_B6YB)
Comments Characteristics: Transfected with a PuroR-ins2-eGFP construct where the expression of the eGFP gene is under the control of the mouse ins2 promoter (PubMed=34871457).
Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic alpha cell; CL=CL_0002351.
Disease Mouse islet cell adenoma (NCIt: C34051)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 x DBA/2.
Hierarchy Parent: CVCL_B036 (alphaTC1 Clone 6)
Sex of cell Sex unspecified
Age at sampling Age unpecified
Category Cancer cell line
Publications

PubMed=34871457; DOI=10.1111/bph.15769
Jian-Xin Jia, Qi Kang, Shun-Zhi Liu, Ya-Bin Song, Florence Susan Wong, Ying-Kun Qiu, Ming-Yu Li;
Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish.
Br. J. Pharmacol. 179:1962-1977(2022)

Cross-references
Encyclopedic resources Wikidata; Q111732917
Entry history
Entry creation17-Mar-2022
Last entry update14-Aug-2025
Version number8