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Cellosaurus iKLF1.1 (CVCL_B6RA)

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Cell line name iKLF1.1
Accession CVCL_B6RA
Resource Identification Initiative To cite this cell line use: iKLF1.1 (RRID:CVCL_B6RA)
Comments Characteristics: Using ZFN a CAG-HA-KLF1-ERT2 construct has been inserted at the AAVS1 safe harbor locus so as to allow temporally controlled activation during macrophage differentiation.
Genetic integration: Method=ZFN; Gene=HGNC; HGNC:3467; ESR1 (Note=Ligand-binding domain; with p.Gly400Val, p.Met543Ala and p.Leu544Ala = ET[T2]).
Genetic integration: Method=ZFN; Gene=HGNC; HGNC:6345; KLF1.
Genetic integration: Method=ZFN; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UL47 (SFCi55)
Sex of cell Female
Category Induced pluripotent stem cell
Publications

PubMed=28026072; DOI=10.1002/stem.2562; PMCID=PMC5396323
Cheng-Tao Yang, Rui Ma, Richard A. Axton, Melany Jackson, A. Helen Taylor, Antonella Fidanza, Lamin Marenah, Jan Frayne, Joanne C. Mountford, Lesley M. Forrester;
Activation of KLF1 enhances the differentiation and maturation of red blood cells from human pluripotent stem cells.
Stem Cells 35:886-897(2017)

Cross-references
Encyclopedic resources Wikidata; Q111733491
Entry history
Entry creation17-Mar-2022
Last entry update14-Aug-2025
Version number7