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Cellosaurus U3-DT (CVCL_B6R9)

[Text version]
Cell line name U3-DT
Accession CVCL_B6R9
Resource Identification Initiative To cite this cell line use: U3-DT (RRID:CVCL_B6R9)
Comments Population: Japanese and Korean.
Senescence: Long term culture of parent cell line (maximum PDL is 252) (PubMed=25978455).
Doubling time: 22 hours (PubMed=25978455).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mesenchymal stem cell of bone marrow; CL=CL_0002540.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3237 (UE6E7T-3)
Sex of cell Female
Age at sampling 91Y
Category Transformed cell line
STR profile Source(s): JCRB=JCRB1136.01

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,13
D7S8208,11
D13S3178
D16S53911
TH019
TPOX9,11
vWA17,18

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Publications

PubMed=25978455; DOI=10.1371/journal.pone.0126562; PMCID=PMC4433180
Masao Takeuchi, Atsunori Higashino, Kikuko Takeuchi, Yutaro Hori, Kazuko Koshiba-Takeuchi, Hatsune Makino, Yoko Monobe, Marina Kishida, Jun Adachi, Jun Takeuchi, Takeshi Tomonaga ...Show all 14 authors... , Akihiro Umezawa, Yosuke Kameoka, Ken-ichi Akagi; Show fewer authors
Transcriptional dynamics of immortalized human mesenchymal stem cells during transformation.
PLoS ONE 10:e0126562.1-e0126562.23(2015)

Cross-references
Cell line collections (Providers) JCRB; JCRB1136.01
Encyclopedic resources Wikidata; Q112041876
Entry history
Entry creation17-Mar-2022
Last entry update14-Aug-2025
Version number11