Cellosaurus cell line TJU-UM004 (CVCL

Cross-references
Cell line name	TJU-UM004
Synonyms	UM004; Thomas Jefferson University-Uveal Melanoma 004
Accession	CVCL_B6PY
Resource Identification Initiative	To cite this cell line use: TJU-UM004 (RRID:CVCL_B6PY)
Comments	Derived from site: Metastatic; Eye socket; UBERON=UBERON_0001697.
Sequence variations	Mutation; HGNC; HGNC:4390; GNAQ; Simple; p.Gln209Pro (c.626A>C); ClinVar=VCV000375957; Zygosity=Homozygous (PubMed=25952648).
Disease	Uveal melanoma (NCIt: C7712) Uveal melanoma (ORDO: Orphanet_39044)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=25952648; DOI=10.1158/0008-5472.CAN-15-0370; PMCID=PMC4490069 Han-Yin Cheng, Mizue Terai, Ken Kageyama, Shinji Ozaki, Peter A. McCue, Takami Sato, Andrew E. Aplin; Paracrine effect of NRG1 and HGF drives resistance to MEK inhibitors in metastatic uveal melanoma. Cancer Res. 75:2737-2748(2015) PubMed=32430489; DOI=10.1158/1535-7163.MCT-19-1016; PMCID=PMC7415561 Jessica L.F. Teh, Timothy J. Purwin, Anna Han, Vivian Chua, Prem Patel, Usman Baqai, Connie Liao, Nelisa Bechtel, Takami Sato, Michael A. Davies, Julio A. Aguirre-Ghiso, Andrew E. Aplin; Metabolic adaptations to MEK and CDK4/6 cotargeting in uveal melanoma. Mol. Cancer Ther. 19:1719-1726(2020)
Cell line databases/resources	cancercelllines; CVCL_B6PY
Encyclopedic resources	Wikidata; Q112041794
Entry history
Entry creation	17-Mar-2022
Last entry update	14-Aug-2025
Version number	8