Cellosaurus cell line TJU-UM003 (CVCL

Cellosaurus TJU-UM003 (CVCL_B6PX)

Cross-references
Cell line name	TJU-UM003
Synonyms	UM003; Thomas Jefferson University-Uveal Melanoma 003
Accession	CVCL_B6PX
Resource Identification Initiative	To cite this cell line use: TJU-UM003 (RRID:CVCL_B6PX)
Comments	Derived from site: Metastatic; Retroperitoneal space; UBERON=UBERON_0003693.
Sequence variations	Mutation; HGNC; HGNC:4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Heterozygous (PubMed=24354797; PubMed=25952648).
Disease	Uveal melanoma (NCIt: C7712) Uveal melanoma (ORDO: Orphanet_39044)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=24354797; DOI=10.1111/pcmr.12206 Makoto Yoshida, Senthamil R. Selvan, Peter A. McCue, Tiziana DeAngelis, Renato Baserga, Ami Fujii, Hallgeir Rui, Michael Joseph Mastrangelo, Takami Sato; Expression of insulin-like growth factor-1 receptor in metastatic uveal melanoma and implications for potential autocrine and paracrine tumor cell growth. Pigment Cell Melanoma Res. 27:297-308(2014) PubMed=25952648; DOI=10.1158/0008-5472.CAN-15-0370; PMCID=PMC4490069 Han-Yin Cheng, Mizue Terai, Ken Kageyama, Shinji Ozaki, Peter A. McCue, Takami Sato, Andrew E. Aplin; Paracrine effect of NRG1 and HGF drives resistance to MEK inhibitors in metastatic uveal melanoma. Cancer Res. 75:2737-2748(2015)
Cell line databases/resources	cancercelllines; CVCL_B6PX
Encyclopedic resources	Wikidata; Q112041793
Entry history
Entry creation	17-Mar-2022
Last entry update	14-Aug-2025
Version number	7