Cellosaurus cell line Mel IL/R (CVCL

Cross-references
Cell line name	Mel IL/R
Accession	CVCL_B6KF
Resource Identification Initiative	To cite this cell line use: Mel IL/R (RRID:CVCL_B6KF)
Comments	Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032). Derived from site: Metastatic; Chest, hypodermis; UBERON=UBERON_0001443+UBERON_0002072.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Unspecified (PubMed=30551515).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_B6KD (Mel Il)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=30551515; DOI=10.1016/j.biopha.2018.11.109 Oxana Ryabaya, Anastasia Prokofieva, Roman Akasov, Dmitry Khochenkov, Marina Emelyanova, Sergey Burov, Elena Markvicheva, Andrey N. Inshakov, Evgenia Vladislavovna Stepanova; Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells. Biomed. Pharmacother. 109:2548-2560(2019)
Cell line databases/resources	cancercelllines; CVCL_B6KF
Encyclopedic resources	Wikidata; Q112129274
Entry history
Entry creation	17-Mar-2022
Last entry update	14-Aug-2025
Version number	7