Cellosaurus cell line HepZ (CVCL

Cellosaurus HepZ (CVCL_B6FC)

Cross-references
Cell line name	HepZ
Accession	CVCL_B6FC
Resource Identification Initiative	To cite this cell line use: HepZ (RRID:CVCL_B6FC)
Comments	Group: Patented cell line. Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2302. Characteristics: Transfected with albumin-promoter regulated antisense constructs against RB1 and TP53. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1582; CCND1. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3113; E2F1. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Hepatocyte; CL=CL_0000182.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=10415582; DOI=10.1111/j.1749-6632.1999.tb08518.x Andreas Werner, Sevim Duvar, Johannes Muthing, Heino Buntemeyer, Uwe Kahmann, Heinrich Lunsdorf, Jurgen Lehmann; Cultivation and characterization of a new immortalized human hepatocyte cell line, HepZ, for use in an artificial liver support system. Ann. N. Y. Acad. Sci. 875:364-368(1999) Patent=US6046050 Michael Strauss, Ira Kirillowa; Human liver cell line. Patent number US6046050, 04-Apr-2000 PubMed=10699872; DOI=10.1002/(SICI)1097-0290(20000405)68:1<59::AID-BIT7>3.0.CO;2-N Andreas Werner, Sevim Duvar, Johannes Muthing, Heino Buntemeyer, Heinrich Lunsdorf, Michael Strauss, Jurgen Lehmann; Cultivation of immortalized human hepatocytes HepZ on macroporous CultiSpher G microcarriers. Biotechnol. Bioeng. 68:59-70(2000)
Encyclopedic resources	Wikidata; Q111733393
Entry history
Entry creation	17-Mar-2022
Last entry update	14-Aug-2025
Version number	7