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Cellosaurus STPDLDS (CVCL_B6BN)

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Cell line name STPDLDS
Synonyms SV40T-Ag and TERT immortalized PerioDontal Ligament Down Syndrome cells
Accession CVCL_B6BN
Resource Identification Initiative To cite this cell line use: STPDLDS (RRID:CVCL_B6BN)
Comments Population: Japanese.
Karyotypic information: Has a large number of abnormal chromosomes (PubMed=34590290).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Tooth, periodontal ligament; UBERON=UBERON_0008266.
Cell type: Fibroblast of periodontal ligament; CL=CL_2000017.
Disease Down syndrome (NCIt: C2993)
Down syndrome (ORDO: Orphanet_870)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 11Y
Category Transformed cell line
STR profile Source(s): PubMed=34590290

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,13
D7S82010
D13S3178,12
D16S53911,14
D21S1129,31.2
TH019,9.3
TPOX11
vWA17,18

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Publications

PubMed=34590290; DOI=10.1007/s13577-021-00621-0; PMCID=PMC8732922
Takeyoshi Asakawa, Atsushi Yamada, Masumi Kugino, Tomokazu Hasegawa, Kentaro Yoshimura, Kiyohito Sasa, Mitsuhiro Kinoshita, Masakazu Nitta, Karin Nagata, Tomomi Sugiyama, Ryutaro Kamijo, Takahiro Funatsu;
Establishment of Down's syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT.
Hum. Cell 35:379-383(2022)

Cross-references
Encyclopedic resources Wikidata; Q112041738
Entry history
Entry creation17-Mar-2022
Last entry update14-Aug-2025
Version number8