Cellosaurus cell line MMH-D2 (CVCL

Cellosaurus MMH-D2 (CVCL_B5WR)

Cross-references
Cell line name	MMH-D2
Synonyms	MMH D2; D2; Met Murine Hepatocytes-D2
Accession	CVCL_B5WR
Resource Identification Initiative	To cite this cell line use: MMH-D2 (RRID:CVCL_B5WR)
Comments	Genetic integration: Method=Transgenic mouse; Gene=HGNC; HGNC:7029; MET (Note=With p.Met1_Leu955del = cyto-Met). Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Hepatocyte; CL=CL_0000182.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell	Sex unspecified
Age at sampling	2D
Category	Spontaneously immortalized cell line
Publications	PubMed=9034332; DOI=10.1093/emboj/16.3.495; PMCID=PMC1169653 Laura Amicone, Francesca Maria Spagnoli, Gerald Frank Spath, Silvia Giordano, Cristina Tommasini, Silvia Bernardini, Veronica De Luca, Carlo Della Rocca, Mary C. Weiss, Paolo Maria Comoglio, Marco Tripodi; Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J. 16:495-503(1997) PubMed=9817765; DOI=10.1083/jcb.143.4.1101; PMCID=PMC2132947 Francesca Maria Spagnoli, Laura Amicone, Marco Tripodi, Mary C. Weiss; Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver. J. Cell Biol. 143:1101-1112(1998) PubMed=9828230; DOI=10.1002/hep.510280626 Alessandro Aiuti, Carla Cicchini, Silvia Bernardini, Giorgio Fedele, Laura Amicone, Antonio Fantoni, Marco Tripodi; Hematopoietic support and cytokine expression of murine-stable hepatocyte cell lines (MMH). Hepatology 28:1645-1654(1998)
Encyclopedic resources	Wikidata; Q112129336
Entry history
Entry creation	17-Mar-2022
Last entry update	19-Dec-2024
Version number	6