Cellosaurus cell line TRNDi042-A (CVCL

Cellosaurus TRNDi042-A (CVCL_B5TR)

Cross-references
Cell line name	TRNDi042-A
Synonyms	NCATS-CL7570; NCATS-CL9554; HT528A; GM29682; GM29682*B
Accession	CVCL_B5TR
Resource Identification Initiative	To cite this cell line use: TRNDi042-A (RRID:CVCL_B5TR)
Comments	From: NIH-NCATS-TRND Branch; Rockville; USA. Population: Caucasian. Cell type: Fibroblast; CL=CL_0000057.
Sequence variations	Mutation; HGNC; HGNC:7632; NAGLU; Simple; p.Arg626Ter (c.1876C>T); ClinVar=VCV000001561; Zygosity=Homozygous (PubMed=39579553).
Disease	Mucopolysaccharidosis type IIIB (NCIt: C84898) Sanfilippo syndrome type B (ORDO: Orphanet_79270)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0L90 (GM00156)
Sex of cell	Male
Age at sampling	7Y
Category	Induced pluripotent stem cell
Publications	PubMed=34411609; DOI=10.1016/j.yexcr.2021.112785; PMCID=PMC8440473 Wei Huang, Yu-Shan Cheng, Shu Yang, Manju Swaroop, Miao Xu, Wen-Wei Huang, Wei Zheng; Disease modeling for mucopolysaccharidosis type IIIB using patient derived induced pluripotent stem cells. Exp. Cell Res. 407:112785.1-112785.10(2021) PubMed=39579553; DOI=10.1016/j.scr.2024.103612; PMCID=PMC11787772 Edwin Alexander Rodriguez-Lopez, Xiu-Li Huang, Catherine Z. Chen, Ji-Zhong Zou, Wei Zheng, Gui-Bin Chen; Generation of an induced pluripotent stem cell line (TRNDi042-A) from a Mucopolysaccharidosis type IIIB patient with homozygous p. R626X (c. 1876C > T) mutation in the NAGLU gene. Stem Cell Res. 81:103612-103612(2024)
Cell line collections (Providers)	Coriell; GM29682
Biological sample resources	BioSample; SAMEA115676041
Encyclopedic resources	Wikidata; Q112129410
Entry history
Entry creation	17-Mar-2022
Last entry update	27-Nov-2025
Version number	6