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Cellosaurus MFUM-BrTNBC-1 (CVCL_B5N7)

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Cell line name MFUM-BrTNBC-1
Synonyms Medical Faculty University of Maribor-Breast Triple Negative Breast Cancer-1
Accession CVCL_B5N7
Resource Identification Initiative To cite this cell line use: MFUM-BrTNBC-1 (RRID:CVCL_B5N7)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian; Slovenian.
Characteristics: Shown by ICC and PCR to be ER-negative, PR-negative and ERBB2-negative (PubMed=35011679).
Doubling time: 80 hours (PubMed=35011679).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:393; AKT3; Simple; p.Lys294Ter (c.880A>T); Zygosity=Heterozygous (PubMed=35011679).
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Tyr2037Ter (c.6111C>G); Zygosity=Heterozygous (PubMed=35011679).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly32Arg (c.94G>C); ClinVar=VCV001690925; Zygosity=Heterozygous (PubMed=35011679).
  • Mutation; HGNC; HGNC:7993; NRBP1; Simple; p.Lys217Ter (c.649A>T); Zygosity=Heterozygous (PubMed=35011679).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=35011679).
  • Mutation; HGNC; HGNC:12816; XPC; Simple; p.Gln829Ter (c.2485C>T); Zygosity=Heterozygous (PubMed=35011679).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): PubMed=35011679

Markers:
AmelogeninX
CSF1PO11
D2S133822,24
D3S135815
D5S81812
D7S8209,11
D8S117912,14
D13S31713,14
D16S53911,12
D18S5112,16
D19S43313,14
D21S1128,31.2
FGA23
TH016
TPOX8,9
vWA17,19

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Publications

PubMed=31749235; DOI=10.1111/tbj.13695
Kristijan Skok, Lidija Gradisnik, Helena Sabina Celesnik, Uros Potocnik, Rajko Kavalar, Iztok Takac, Uros Maver;
Isolation and characterization of the first Slovenian human triple-negative breast cancer cell line.
Breast J. 26:328-330(2020)

PubMed=35011679; DOI=10.3390/cells11010117; PMCID=PMC8749978
Kristijan Skok, Lidija Gradisnik, Helena Sabina Celesnik, Marko Milojevic, Uros Potocnik, Gregor Jezernik, Mario Gorenjak, Monika Sobocan, Iztok Takac, Rajko Kavalar, Uros Maver;
MFUM-BrTNBC-1, a newly established patient-derived triple-negative breast cancer cell line: molecular characterisation, genetic stability, and comprehensive comparison with commercial breast cancer cell lines.
Cells 11:117.1-117.23(2022)

Cross-references
Encyclopedic resources Wikidata; Q112129315
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number6