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Cellosaurus HGS4 (CVCL_B5GY)

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Cell line name HGS4
Accession CVCL_B5GY
Resource Identification Initiative To cite this cell line use: HGS4 (RRID:CVCL_B5GY)
Comments Characteristics: When injected i.p. produces omental tumors and metastases to splenoportal fat, lesser omentum, and mesentery, with extensive disease established by 12-20 weeks (PubMed=31940494).
Knockout cell: Method=KO mouse; MGI; MGI:109337; Brca2 (Note=1 of 2 alleles).
Knockout cell: Method=KO mouse; MGI; MGI:109583; Pten.
Knockout cell: Method=KO mouse; MGI; MGI:98834; Trp53.
Derived from site: In situ; Mesentery; UBERON=UBERON_0002095.
Disease Mouse ovarian serous adenocarcinoma (NCIt: C33903)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: B6.129P2-Trp53tm1Brn/J.Ptenfl/f x C57BL/6J-Brca2fl/fl.
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=31940494; DOI=10.1016/j.celrep.2019.12.034; PMCID=PMC6963791
Eleni Maniati, Chiara Berlato, Ganga Gopinathan, Owen Heath, Panoraia Kotantaki, Anissa Lakhani, Jacqueline McDermott, Colin Pegrum, Robin M. Delaine-Smith, Oliver M.T. Pearce, Priyanka Hirani ...Show all 18 authors... , Joash D. Joy, Ludmila Szabova, Ruth Perets, Owen James Sansom, Ronny I. Drapkin, Peter Bailey, Frances Rosemary Balkwill; Show fewer authors
Mouse ovarian cancer models recapitulate the human tumor microenvironment and patient response to treatment.
Cell Rep. 30:525-540.e7(2020)

Cross-references
Cell line collections (Providers) CancerTools; 160540
Ximbio; 160540
Encyclopedic resources Wikidata; Q110432895
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number7