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Cellosaurus HeLa1.3 hTR-50-3xMS2 TERT-/- (CVCL_B5DH)

[Text version]
Cell line name HeLa1.3 hTR-50-3xMS2 TERT-/-
Synonyms HeLa 1.3 hTR-50-3xMS2 TERT-/-
Accession CVCL_B5DH
Resource Identification Initiative To cite this cell line use: HeLa1.3 hTR-50-3xMS2 TERT-/- (RRID:CVCL_B5DH)
Comments Population: African American.
Characteristics: Using CRISPR/Cas9 3 MS2 stem loops sequences flanked by homologous telomerase RNA (hTR) sequences were knocked in.
Characteristics: Has exceptionally long telomeres of approximately 23 kb in length (from parent cell line).
Knockout cell: Method=CRISPR/Cas9; HGNC; 11730; TERT.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B5DF (HeLa1.3 hTR-50-3xMS2)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=32497497; DOI=10.1016/j.molcel.2020.05.005
Laprade H., Querido E., Smith M.J., Guerit D., Crimmins H., Conomos D., Pourret E., Chartrand P., Sfeir A.
Single-molecule imaging of telomerase RNA reveals a recruitment-retention model for telomere elongation.
Mol. Cell 79:115-126.e6(2020)

Cross-references
Encyclopedic resources Wikidata; Q110432888
Entry history
Entry creation16-Dec-2021
Last entry update05-Oct-2023
Version number5