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Cellosaurus K562 BZQR (CVCL_B502)

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Cell line name K562 BZQR
Synonyms K562BZQR; BZQR
Accession CVCL_B502
Resource Identification Initiative To cite this cell line use: K562 BZQR (RRID:CVCL_B502)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90193; NSC-224070 (BZQ; 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): PubMed=11416159

Markers:
AmelogeninX
D8S117912
D18S5116
D21S1129,30
FGA21,24
TH019.3
vWA16

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Publications

PubMed=7646550; DOI=10.1016/0006-2952(95)00155-S
Timothy H. Ward, M. Sally Haran, Dee Whittaker, Amanda Jean Watson, Tina D. Howard, John Butler;
Cross-resistance studies on two K562 sublines resistant to diaziridinylbenzoquinones.
Biochem. Pharmacol. 50:459-464(1995)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

Cross-references
Encyclopedic resources Wikidata; Q54899292
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number23