Cellosaurus cell line iChEC-1 (CVCL

Cellosaurus iChEC-1 (CVCL_B4IK)

Cross-references
Cell line name	iChEC-1
Synonyms	immortalized Choroidal Endothelial Cell-1
Accession	CVCL_B4IK
Resource Identification Initiative	To cite this cell line use: iChEC-1 (RRID:CVCL_B4IK)
Comments	Population: Caucasian. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Eye, choroid; UBERON=UBERON_0001776. Cell type: Endothelial cell; CL=CL_0000115.
Sequence variations	Mutation; HGNC; HGNC:4883; CFH; Simple; p.Val62Ile (c.184G>A); ClinVar=VCV000016550; Zygosity=Homozygous (PubMed=30571950). Mutation; HGNC; HGNC:13941; SLC44A4; Simple; p.Asp123Val (c.368A>T); dbSNP=rs12661281; Zygosity=Homozygous (PubMed=30571950).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	1M
Category	Transformed cell line
Publications	PubMed=30571950; DOI=10.1016/j.mvr.2018.12.002; PMCID=PMC7401191 Joseph C. Giacalone, Matthew J. Miller, Grefachew Workalemahu, Austin J. Reutzel, Dalyz Ochoa, S. Scott Whitmore, Edwin M. Stone, Budd A. Tucker, Robert F. Mullins; Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter. Microvasc. Res. 123:50-57(2019)
Encyclopedic resources	Wikidata; Q110432916
Entry history
Entry creation	16-Dec-2021
Last entry update	14-Aug-2025
Version number	8