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Cellosaurus IW32 (CVCL_B4H1)

[Text version]
Cell line name IW32
Synonyms IW.32
Accession CVCL_B4H1
Resource Identification Initiative To cite this cell line use: IW32 (RRID:CVCL_B4H1)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-234.
Characteristics: Constitutively synthesizes and secretes erythropoietin (PubMed=6578507; PubMed=6589018).
Characteristics: One of the two copies of the EPO locus has undergone rearrangement and amplification (PubMed=2766927; PubMed=3561395).
Transformant: NCBI_TaxID; 11795; Friend murine leukemia virus (FrMLV).
Disease Mouse erythroid leukemia (NCIt: C21895)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: ICFW.
Category Cancer cell line
Publications

PubMed=6578507; DOI=10.1073/pnas.80.20.6269; PMCID=PMC394277
Pierre Tambourin, Nicole Casadevall, Jeannine Choppin, Catherine Lacombe, Jean-Michel Heard, Serge Fichelson, Francoise Wendling, W. David Hankins, Bruno Varet;
Production of erythropoietin-like activity by a murine erythroleukemia cell line.
Proc. Natl. Acad. Sci. U.S.A. 80:6269-6273(1983)

PubMed=6589018; DOI=10.1182/blood.V64.2.341.341
Jeannine Choppin, Catherine Lacombe, Nicole Casadevall, Otfried Muller, Pierre Tambourin, Bruno Varet;
Characterization of erythropoietin produced by IW32 murine erythroleukemia cells.
Blood 64:341-347(1984)

Patent=FR2550216A1
Jean-Paul Levy, Bruno Varet;
New cell line, its production and its application in the preparation of a factor having erythropoietic activity.
Patent number FR2550216A1, 08-Feb-1985

PubMed=3861324
Jeannine Choppin, Nicole Casadevall, Catherine Lacombe, Francoise Wendling, Eugene Goldwasser, Roland Berger, Pierre Tambourin, Bruno Varet;
Production of erythropoietin by cloned malignant murine erythroid cells.
Exp. Hematol. 13:610-615(1985)

PubMed=3561395; DOI=10.1128/mcb.7.1.365-370.1987; PMCID=PMC365077
Jeffrey McDonald, Nega Beru, Eugene Goldwasser;
Rearrangement and expression of erythropoietin genes in transformed mouse cells.
Mol. Cell. Biol. 7:365-370(1987)

PubMed=2735652; DOI=10.1111/j.1749-6632.1989.tb22406.x
Nega Beru, Jeffrey McDonald, Eugene Goldwasser;
Studies of the constitutive expression of the mouse erythropoietin gene.
Ann. N. Y. Acad. Sci. 554:29-35(1989)

PubMed=2766927; DOI=10.1089/dna.1.1989.8.253
Nega Beru, Jeffrey McDonald, Eugene Goldwasser;
Activation of the erythropoietin gene due to the proximity of an expressed gene.
DNA 8:253-259(1989)

PubMed=2355917; DOI=10.1128/mcb.10.7.3591-3595.1990; PMCID=PMC360795
Nega Beru, Phillip B. Maples, Olivier Hermine, Eugene Goldwasser;
Differential expression of alpha- and beta-globin genes in erythroleukemic cell lines.
Mol. Cell. Biol. 10:3591-3595(1990)

Cross-references
Encyclopedic resources Wikidata; Q110432993
Entry history
Entry creation16-Dec-2021
Last entry update21-Mar-2023
Version number3