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Cellosaurus MODE-K (CVCL_B4FG)

[Text version]
Cell line name MODE-K
Synonyms Mode-K
Accession CVCL_B4FG
Resource Identification Initiative To cite this cell line use: MODE-K (RRID:CVCL_B4FG)
Comments Doubling time: 15 hours (PubMed=7693823).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Small intestine, duodenum; UBERON=UBERON_0002114.
Cell type: Epithelial cell of intestine; CL=CL_0002563.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/HeJ.
Hierarchy Children:
CVCL_B4FH (MODE-K.CD150)CVCL_B4FI (MODE-K.CD46)CVCL_E0Z8 (Ubigene MODE-K Gpx4 KO)
CVCL_E0Z9 (Ubigene MODE-K Hsp90ab1 KO)
Sex of cell Female
Category Transformed cell line
Publications

PubMed=7693823; DOI=10.1016/0022-1759(93)90329-6
Karine Vidal, Isabelle Grosjean, Jean-Pierre Revillard, Christian Gespach, Dominique Kaiserlian;
Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. Phenotypic and immune characterization of the MODE-K cell line.
J. Immunol. Methods 166:63-73(1993)

PubMed=12021345; DOI=10.1128/JVI.76.12.6121-6130.2002; PMCID=PMC136230
Severine Vincent, Isabelle Tigaud, Henriette Schneider, Christian J. Buchholz, Yusuke Yanagi, Denis Gerlier;
Restriction of measles virus RNA synthesis by a mouse host cell line: trans-complementation by polymerase components or a human cellular factor(s).
J. Virol. 76:6121-6130(2002)

PubMed=32304812; DOI=10.1016/j.fct.2020.111331
Diomira Luongo, Lucia Treppiccione, Francesco Maurano, Mauro Rossi, Paolo Bergamo;
The murine enterocyte cell line Mode-K is a novel and reliable in vitro model for studies on gluten toxicity.
Food Chem. Toxicol. 140:111331.1-111331.9(2020)

Cross-references
Encyclopedic resources Wikidata; Q110433061
Entry history
Entry creation16-Dec-2021
Last entry update14-Aug-2025
Version number7