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Cellosaurus TR14 (CVCL_B474)

[Text version]
Cell line name TR14
Synonyms TR-14
Accession CVCL_B474
Resource Identification Initiative To cite this cell line use: TR14 (RRID:CVCL_B474)
Comments Doubling time: 3 days (PubMed=6861117).
Omics: Transcriptome analysis by microarray.
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line

PubMed=6861117; DOI=10.1016/0165-4608(83)90011-0
Cowell J.K., Rupniak H.T.
Chromosome analysis of human neuroblastoma cell line TR14 showing double minutes and an aberration involving chromosome 1.
Cancer Genet. Cytogenet. 9:273-280(1983)

Rupniak H.T., Rein G., Powell J.F., Ryder T.A., Carson S., Povey S., Hill B.T.
Characteristics of a new human neuroblastoma cell line which differentiates in response to cyclic adenosine 3':5'-monophosphate.
Cancer Res. 44:2600-2607(1984)

Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7
Van Roy N., Jauch A., Van Gele M., Laureys G., Versteeg R., De Paepe A., Cremer T., Speleman F.
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer Genet. Cytogenet. 97:135-142(1997)

PubMed=9516836; DOI=10.1016/S0959-8049(97)00319-5
Van Roy N., Laureys G., Van Gele M., Opdenakker G., Miura R., van der Drift P., Chan A., Versteeg R., Speleman F.
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
Eur. J. Cancer 33:1974-1978(1997)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004
Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

Encyclopedic resources Wikidata; Q54972929
Gene expression databases GEO; GSM692868
Polymorphism and mutation databases Cosmic; 1109113
Cosmic; 1518080
Cosmic; 1526657
Cosmic; 2239466
IARC_TP53; 23836
Entry history
Entry creation06-Jun-2012
Last entry update21-Mar-2023
Version number12