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Cellosaurus TR14 (CVCL_B474)

[Text version]
Cell line name TR14
Synonyms TR-14
Accession CVCL_B474
Resource Identification Initiative To cite this cell line use: TR14 (RRID:CVCL_B474)
Comments Doubling time: 3 days (PubMed=6861117).
Omics: Genomics; Extrachromosomal circular DNA (scEC); Single cell.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq; Single cell.
Miscellaneous: STR profile from personal communication of Henssen, Anton George & Roefzaad, Claudia.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,11,12,13
D2S133818,23
D3S135817
D5S81811,12,13,14
D7S82010,11,12
D8S117914,15,16,17
D13S31710,11
D16S53910,11,12
D18S5112,15,16
D19S43312,13
D21S1128,29,30,31,32
FGA19,20,21,22
TH016,7
TPOX9,11,12
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=6861117; DOI=10.1016/0165-4608(83)90011-0
John Kenneth Cowell, H. Thomas Rupniak;
Chromosome analysis of human neuroblastoma cell line TR14 showing double minutes and an aberration involving chromosome 1.
Cancer Genet. Cytogenet. 9:273-280(1983)

PubMed=6144383
H. Thomas Rupniak, Glen Rein, John F. Powell, Tim A. Ryder, Susan Carson, Susan Povey, Bridget T. Hill;
Characteristics of a new human neuroblastoma cell line which differentiates in response to cyclic adenosine 3':5'-monophosphate.
Cancer Res. 44:2600-2607(1984)

PubMed=7838528
Ngan Ching Cheng, Nadine Van Roy, Alvin Chan, Mabel Beitsma, Andries Westerveld, Frank Speleman, Rogier Versteeg;
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7
Nadine Van Roy, Anna Jauch, Mireille Van Gele, Genevieve Laureys, Rogier Versteeg, Anne De Paepe, Thomas Cremer, Frank Speleman;
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer Genet. Cytogenet. 97:135-142(1997)

PubMed=9516836; DOI=10.1016/S0959-8049(97)00319-5
Nadine Van Roy, Genevieve Laureys, Mireille Van Gele, Ghislain Opdenakker, R. Miura, Pauline van der Drift, Alvin Chan, Rogier Versteeg, Frank Speleman;
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
Eur. J. Cancer 33:1974-1978(1997)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=39255063; DOI=10.1016/j.celrep.2024.114711
Maja-Celine Stober, Rocio Chamorro Gonzalez, Lotte Bruckner, Thomas Conrad, Nadine Wittstruck, Annabell Krienelke Szymansky, Angelika Eggert, Johannes Hubertus Schulte, Richard Patrick Koche, Anton George Henssen, Roland F. Schwarz, Kerstin Haase;
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Cell Rep. 43:114711.1-114711.19(2024)

Cross-references
Encyclopedic resources Wikidata; Q54972929
Gene expression databases GEO; GSM692868
Polymorphism and mutation databases Cosmic; 1109113
Cosmic; 1518080
Cosmic; 1526657
Cosmic; 2239466
IARC_TP53; 23836
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number15