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Cellosaurus NCC-CCS1-X4-C1 (CVCL_B3TR)

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Cell line name NCC-CCS1-X4-C1
Synonyms NCCCCS1X4C1
Accession CVCL_B3TR
Resource Identification Initiative To cite this cell line use: NCC-CCS1-X4-C1 (RRID:CVCL_B3TR)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Characteristics: Established from a fourth generation xenograft established by subcutaneous injection in female NOD/Shi-scid IL-2Rgammanull mice.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
Doubling time: 17 hours (PubMed=29197033).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Left thigh, hypodermis; UBERON=UBERON_0000376+UBERON_0002072.
Sequence variations
Disease Clear cell sarcoma of soft tissue (NCIt: C3745)
Soft tissue sarcoma (ORDO: Orphanet_3394)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B3TS ! NCC-CCS1B-C1
CVCL_B3TT ! NCC-CCS1B-X2-C1
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): PubMed=29197033; PubMed=36959380

Markers:
AmelogeninX
CSF1PO10
D3S135817
D5S81811
D7S82011,12
D8S117912,14
D13S3178
D16S53911
D18S5116,19
D21S1130,31 (PubMed=29197033)
31 (PubMed=36959380)
FGA23
Penta D12
Penta E12,19
TH016
TPOX11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=29197033; DOI=10.1007/s11626-017-0207-5
Marimu Sakumoto, Rieko Oyama, Mami Takahashi, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhi-Wei Qiao, Makoto Endo, Akihiko Yoshida, Akira Kawai, Tadashi Kondo;
Establishment and proteomic characterization of patient-derived clear cell sarcoma xenografts and cell lines.
In Vitro Cell. Dev. Biol. Anim. 54:163-176(2018)

PubMed=36959380; DOI=10.1038/s41416-023-02222-0; PMCID=PMC10147623
Samuel V. Rasmussen, Agnieszka Wozniak, Melvin Lathara, Joshua M. Goldenberg, Benjamin Michael Samudio, Lissett Ramirez Bickford, Kiyo Nagamori, Hollis Wright, Andrew D. Woods, Shefali Chauhan, Che-Jui Lee ...Show all 30 authors... , Erin R. Rudzinski, Michael K. Swift, Tadashi Kondo, David Erich Fisher, Evgeny N. Imyanitov, Isidro Machado, Antonio Llombart-Bosch, Irene L. Andrulis, Nalan Gokgoz, Jay Steven Wunder, Hiroshi Moritake, Takuro Nakamura, Ganapati Srinivasa, Khin Thway, Robin L. Jones, Paul H. Huang, Noah E. Berlow, Patrick Schoffski, Charles Keller; Show fewer authors
Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma.
Br. J. Cancer 128:1941-1954(2023)

Cross-references
Cell line databases/resources DepMap; ACH-002793
Encyclopedic resources Wikidata; Q110433080
Sequence databases EGA; EGAD00001008611
Entry history
Entry creation16-Dec-2021
Last entry update27-Nov-2025
Version number9