Cellosaurus cell line Rag2-/- pro-B cells (CVCL

Cellosaurus Rag2-/- pro-B cells (CVCL_B3QD)

Cross-references
Cell line name	Rag2-/- pro-B cells
Synonyms	RAG2KO pro-B cells
Accession	CVCL_B3QD
Resource Identification Initiative	To cite this cell line use: Rag2-/- pro-B cells (RRID:CVCL_B3QD)
Comments	Characteristics: Rag2-/- pro-B cells maintained on OP42 stromal cells. Knockout cell: Method=KO mouse; MGI; MGI:97849; Rag2. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. Cell type: Pro-B cell; CL=CL_0000826.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: 129S6/SvEvTac-Rag2tm1Fwa.
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Finite cell line
Publications	PubMed=16025120; DOI=10.1038/ni1226 Eric Bertolino, Karen L. Reddy, Kay Lynn Medina, Evan Parganas, James N. Ihle, Harinder Singh; Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat. Immunol. 6:836-843(2005) PubMed=18176567; DOI=10.1038/ni1555 Jagan M.R. Pongubala, Daniel L. Northrup, David W. Lancki, Kay Lynn Medina, Thomas Treiber, Eric Bertolino, Matthew Thomas, Rudolf Grosschedl, David Allman, Harinder Singh; Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat. Immunol. 9:203-215(2008) PubMed=20971928; DOI=10.4049/jimmunol.0904203; PMCID=PMC3907951 Kimberly Gwin, Elena Frank, Ayoko R. Bossou, Kay Lynn Medina; Hoxa9 regulates Flt3 in lymphohematopoietic progenitors. J. Immunol. 185:6572-6583(2010)
Encyclopedic resources	Wikidata; Q110433158
Entry history
Entry creation	16-Dec-2021
Last entry update	29-Jun-2023
Version number	4